LKT Labs
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Acetylsalicylic Acid
LKT LabsNSAID and COX-1/2 inhibitor used to decrease inflammation. It inhibits platelet aggregation and prolongs bleeding time by decreasing levels of thromboxane A2. Chronic administration decreases risk of cancer and cardiovascular events.
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Cisplatin
LKT LabsCisplatin is a platinum-based cross-linking agent that exhibits anticancer chemotherapeutic activity. Cisplatin induces crosslinks between guanine bases on DNA; it is clinically used to treat various forms of cancer. In lung cancer cells, cisplatin decreases phosphorylation of PI3K, Akt, and FOXO3a…
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Carbamazepine
LKT LabsCarbamazepine is an antiepileptic/anticonvulsant that also exhibits antipsychotic and anti-inflammatory activities. Carbamazepine inhibits voltage-gated Na+ channels, stabilizing the inactive conformation of the channel. Carbamazepine also potentiates GABA receptor signaling and inhibits…
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Altretamine
LKT LabsAltretamine is an anticancer chemotherapeutic agent that binds DNA at guanine and cytosine residues, forming DNA adducts. This alkylating agent is also metabolized to formaldehyde. Altretamine is clinically used to treat ovarian cancer.
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Calcitonin, chicken
LKT LabsCalcitonin is an endogenous neuropeptide that exhibits pro-oncogenic, anti-osteoarthritic, and anti-resorptive activities. Calcitonin induces activation of NF-?B, upregulating expression and activity of fibronectin, MMP-1, MMP-2, and MMP-9 and increasing cell growth in osteosarcoma cells. When…
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3-tert-Butyl-4-Hydroxyanisole
LKT Labs3-Tert-butyl-4-hydroxyanisole (3-BHA) is one component of butylated hydroxyanisole (BHA). This compound is commonly used as a food additive; it exhibits antioxidative and anticancer activities. In leukemia cells, 3-BHA decreases the mitochondrial membrane potential, inhibits mitochondrial oxidative…
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Allyl Disulfide
LKT LabsAllyl disulfide is an organosulfur originally found in garlic that exhibits antioxidative, antiviral, neuroprotective, anti-parasitic, anticancer, and anti-hyperlipidemic activities. Allyl disulfide induces phase II enzymes, inhibits lipid peroxidation, and acts as a radical scavenger. In vitro,…
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CAY10505
LKT LabsCAY10505 is an inhibitor of p110? PI3K. CAY10505 increases endothelial relaxation, normalizes levels of glutathione, nitrate, and nitrite, and alters the vascular endothelial lining in hypertensive rats, improving vascular endothelial dysfunction. Grade: ≥98%
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Bis(3,5-dibromosalicyl) Fumarate
LKT LabsBis(3,5-dibromosalicyl) fumarate is an aspirin analog that is used to induce hemoglobin chain crosslinks at lysine residues. This compound is used to study hemoglobin function in research models and may be used to develop treatments for sickle-cell anemia. This compound may exhibit…
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Adenine
LKT LabsAdenine is a purine nucleotide base that is involved in the synthesis of RNA and DNA. Adenine also plays roles in cellular respiration as a component of ATP, NAD, and FAD. Grade: ≥98%
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Anabaenopeptin 872
LKT LabsAnabaenopeptins are cyclopentapeptides found in cyanobacteria such as Microcystis aeruginosa and Oscillatoria agardhii. Anabaenopeptins and other cyanotoxins are typically inhibitors of serine proteases and protein phosphatases (PPs). Anabaenopeptins may also inhibit carboxypeptidases.…
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Cholesterol
LKT LabsCholesterol is a sterol component of animal cell membranes that is required for membrane fluidity. Cholesterol is also the precursor to most steroid hormones, bile acids, and vitamin D compounds. Additionally, cholesterol is involved in vesicular transport and nerve conduction, and shows some…
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Boc-GRR-AMC
LKT LabsThis peptide is a protease substrate that is used to measure protease activity in vitro. This peptide can bind to serine proteases such as cathepsins. Grade: ≥98%
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C59
LKT LabsC59 is a PORCN inhibitor that exhibits anticancer chemotherapeutic activity, inhibiting the progression of mammary tumors in vivo by downregulating Wnt signaling. Grade: ≥98%
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ß-Casomorphin, human
LKT Labsß-Casomorphin is a peptide fragment of casein that exhibits antioxidative and anti-fibrotic activities. In vivo, ß-casomorphin improves high glucose-induced changes in oxidative enzyme secretion and activity. ß-Casomorphin also decreases urinary glucose and protein levels as well as serum creatine…
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Dihydroartemisinin
LKT LabsDihydroartemisinin is a sesquiterpene lactone that can be derived from Artemisia. Dihydroartemisinin exhibits anticancer, antiviral, anti-inflammatory, anti-asthma, and anti-parasitic activities. Artemisinins such as dihydroartemisinin are best known for their antimalarial activity.…
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Azithromycin Dihydrate
LKT LabsAzithromycin is an azalide macrolide antibiotic derived from erythromycin. Azithromycin binds the bacterial 50S ribosomal subunit, inhibiting protein translation. Azithromycin displays antibacterial, anti-fibrotic, and anti-inflammatory activities. In epithelial cells, azithromycin inhibits the…
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Aflatoxin B2
LKT LabsAflatoxins are mycotoxins found in foods and livestock feeds that were initially produced by species of Aspergillus. Aflatoxin B2 is cytotoxic; it inhibits DNA synthesis and induces cell cycle arrest.
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Aflatoxin M1
LKT LabsAflatoxins are mycotoxins found in foods and livestock feeds that were initially produced by species of Aspergillus. Aflatoxin M1 is the hydroxylated metabolite of aflatoxin B1; it inhibits DNA synthesis and induces cell cycle arrest.
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Bongkrekic Acid
LKT LabsBongkrekic acid is an antioxidative compound that inhibits mitochondrial respiration by preventing the mitochondrial permeability transition (MPT); it suppresses transport of ADP/ATP across the mitochondrial inner membrane, decreasing oxidative stress. Grade: ≥98%
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Ciprofloxacin is a second generation fluoroquinolone antibiotic that exhibits antibacterial activity against both gram negative and gram positive bacteria. Ciprofloxacin inhibits DNA gyrase and topoisomerase IV, preventing DNA replication.
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Bulleyaconitine A
LKT LabsBulleyaconitine A (BLA) is found in Aconitum bulleyanum and exhibits analgesic and anesthetic activity. BLA has been used as a treatment for a variety of pain-related and inflammatory disorders. BLA inhibits voltage-gated Na+ channels in a use-dependent manner, reducing peak Na+ currents during…
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Carcinoembryonic Antigen (605-613)
LKT LabsThis peptide is an epitope of carcinoembryonic antigen and is recognized by T cells in the immune system; it may have potential in the development of vaccines or targeting therapies. Grade: ≥95%
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Bromosporine
LKT LabsBromosporine is an inhibitor of BET bromodomains (BRDs) BRD2, BRD4, BRD9, and CECR2; it may exhibit anticancer potential.
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Boc-RRR-AMC
LKT LabsThis peptide is a protease substrate that is used to measure protease activity in vitro. This peptide can bind to serine proteases such as cathepsins. Grade: ≥98%
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2-tert-Butyl-4-Hydroxyanisole
LKT Labs2-Tert-butyl-4-hydroxyanisole (2-BHA) is one component of butylated hydroxyanisole (BHA). This compound is commonly used as a food additive; it exhibits antioxidative activity. 2-BHA acts as a phase II enzyme inducer, increasing levels of glutathione and glutathione-S-transferase.
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Chlorambucil
LKT LabsChlorambucil is a nitrogen mustard anticancer chemotherapeutic that acts as an alkylating agent. Chlorambucil is clinically used to treat chronic lymphocytic leukemia (CLL).,
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Bleomycin Sulfate
LKT LabsThis product is a mixture of bleomycin sulfate salts; bleomycin A2 is pictured. Bleomycin is an anticancer chemotherapeutic that binds DNA and induces DNA cleavage and strand breaks; it is highly toxic. Bleomycin A5 is clinically used to treat lymphomas, squamous cell carcinomas, and testicular…
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ALAL
LKT LabsALAL is a peptide sequence commonly used as a linker to conjugate compounds together to better target delivery of anticancer chemotherapeutics. Grade: ≥95%
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Chlorpheniramine Maleate
LKT LabsChlorpheniramine is a first generation alkylamine antihistamine that inhibits H1 histamine receptors, serotonin transporters (SERT), and norepinephrine transporters (NET); it exhibits anti-allergic and antidepressant activities. Chlorpheniramine is clinically used to treat allergic rhinitis and…
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Carvedilol
LKT LabsCarvedilol is an a1- and ß1/2-adrenergic receptor antagonist used to treat congestive heart failure; its inhibitory action at adrenergic receptors slows heart rhythm, decreasing force, pressure, and cardiac workload. Carvedilol also inhibits release of pro-inflammatory cytokines TNF-a and…
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9-Nitro-20S-camptothecin
LKT Labs9-nitro-20S-Camptothecin is a camptothecin derivative. Camptothecin is a quinolone alkaloid precursor of irinotecan; it is originally found in Camptotheca. Camptothecin exhibits anticancer chemotherapeutic activity, inhibiting topoisomerase I and inducing double-stranded DNA breaks. Camptothecin is…