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  • 5-Aza-2'-deoxycytidine

    LKT Labs

    ,p>Decitabine is a deoxycytidine analog that is incorporated into DNA, inhibiting DNA methyltransferase (DNMT1/3A/3B) activity. This demethylating agent is clinically used to treat myelodysplastic syndromes. Decitabine’s inhibition of DNA methyltransferase may be modulated by PKC. Decitabine…

  • Atropine

    LKT Labs

    Atropine is a tropane alkaloid found in plants in the Solanaceae family. Atropine is an anticholinergic compound that also exhibits analgesic and antinociceptive activities. Atropine is a competitive inhibitor of muscarinic acetylcholine receptors (mAChRs) that is commonly used for ophthalmic…

  • ß-Amyloid Peptide (1-40), rat

    LKT Labs

    Amyloid-ß (Aß) is a peptide cleavage product of amyloid precursor protein (APP) that is often used as a biomarker in Alzheimer’s disease. Misfolded Aß oligomers instigate conformation changes in other, normally folded Aß oligomers, increasing the number of misfolded proteins and eventually forming…

  • Azaperone

    LKT Labs

    Azaperone is a butyrophenone tranquilizer that exhibits sedative activity through the inhibition of a-adrenergic receptors. Azaperone also inhibits dopamine receptors and histamine receptors; it also may display antiemetic, antipsychotic, antihistaminergic, and anticholinergic activities.

  • A-K-R-R-R-L-S-S-L-R-A

    LKT Labs

    This peptide is also known as S6 and is used as a phosphorylatable substrate for Rho-associated protein kinase 2 (ROCK-2).

  • ß-Carotene

    LKT Labs

    ß-Carotene is a red-orange terpene pigment originally found in various plants and fruits; it is a prodrug for vitamin A. ß-Carotene exhibits antioxidative, cytoprotective, anticancer, anti-inflammatory, anti-hyperlipidemic, and anti-obesity activities. ß-Carotene is used in research models to…

  • Calcitonin Gene Related Peptide (8-37), human

    LKT Labs

    Calcitonin gene-related peptide (CGRP) (8-37) inhibits the CGRP receptor and is used in research studies to examine the effects of CGRP. CGRP (8-37) inhibits the effects of ghrelin and induces caspase 3-mediated apoptosis in retinal cells of animal models of coronary artery occlusion. Like CGRP,…

  • Cetirizine Dihydrochloride

    LKT Labs

    Cetirizine is a second generation antihistamine that exhibits anti-inflammatory, immunomodulatory, and anti-allergic activities. Cetirizine inhibits histamine H1 receptors and is used to treat dermatitis in clinical settings. In vitro, cetirizine inhib Grade: ≥99%

  • Ambroxol Hydrochloride

    LKT Labs

    Ambroxol is a bronchial expectorant that also exhibits antioxidative activity. Ambroxol stimulates the ciliary beat frequency and increases mucous secretion in the lung and trachea. In clinical settings, ambroxol increases levels of thioredoxin and thioredoxin reductase, decreasing oxidative stress…

  • Azithromycin Dihydrate

    LKT Labs

    Azithromycin is an azalide macrolide antibiotic derived from erythromycin. Azithromycin binds the bacterial 50S ribosomal subunit, inhibiting protein translation. Azithromycin displays antibacterial, anti-fibrotic, and anti-inflammatory activities. In epithelial cells, azithromycin inhibits the…

  • N-(4-Carbethoxyphenyl)retinamide

    LKT Labs

    N-(4-Carbethoxyphenyl)retinamide is a retinoid that exhibits anticancer chemotherapeutic and chemopreventive activities. This compound inhibits development of stomach and oral cancers in vivo and shows some benefit in the treatment of dysplasias. Additionally, this compound induces differentiation…

  • Clodronate Disodium Tetrahydrate

    LKT Labs

    Clodronate is a first-generation non-nitrogen-containing bisphosphonate that is used clinically for its anti-resorptive activity. Clodronate generates formation of a non-hydrolysable ß-? ATP analog that inhibits mitochondrial ADP/ATP translocase and prevents mitochondrial oxygen consumption…

  • Carfilzomib

    LKT Labs

    Carfilzomib is an analog of epoxomicin that functions as a proteasome inhibitor. This drug has been approved for use in humans with multiple myeloma. Carfilzomib binds irreversibly to the 20S proteasome, which exhibits chymotrypsin-like activity and is responsible for degradation of cellular…

  • Actinomycin

    LKT Labs

    Actinomycin D is a polypeptide antibiotic produced from Streptomyces; it exhibits anticancer chemotherapeutic activity but does not display antibacterial benefit. Actinomycin D is clinically used to treat various cancers and is one component of the VAC chemotherapy regimen. Actinomycin D binds DNA,…

  • Calyculin A

    LKT Labs

    Calyculin A is an inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A) that was first found in Discodermia. Grade: ≥98%

  • Carprofen

    LKT Labs

    Carprofen is a non-steroidal anti-inflammatory drug (NSAID) that is used in veterinary medicine. Carprofen selectively inhibits COX2. Grade: ≥98%

  • Asparaginase

    LKT Labs

    Asparaginase is an enzyme that catalyzes the hydrolysis of asparagine to aspartate and ammonia, depleting asparagine levels and inhibiting cell growth; it is commonly used as an anticancer chemotherapeutic and anti-angiogenic compound in the treatment of leukemia. Asparaginase inhibits…

  • Chloramphenicol

    LKT Labs

    Chloramphenicol is an antibiotic compound that binds the 50S subunit of the bacterial ribosome, suppressing mitochondrial protein translation; it inhibits peptidyl transferase, preventing translocation. Chloramphenicol exhibits antibacterial activity against Streptomyces.

  • Aflatoxin B1

    LKT Labs

    Aflatoxins are mycotoxins found in foods and livestock feeds that were initially produced by species of Aspergillus. Aflatoxin B1 is the most cytotoxic of all aflatoxins; it inhibits DNA synthesis and induces cell cycle arrest.

  • Aristolochic Acid C

    LKT Labs

    Aristolochic acid C is a carcinogenic compound found in Aristolochia and Radix that has commonly been used in traditional Chinese medicine.

  • 3-tert-Butyl-4-Hydroxyanisole

    LKT Labs

    3-Tert-butyl-4-hydroxyanisole (3-BHA) is one component of butylated hydroxyanisole (BHA). This compound is commonly used as a food additive; it exhibits antioxidative and anticancer activities. In leukemia cells, 3-BHA decreases the mitochondrial membrane potential, inhibits mitochondrial oxidative…

  • Borrelidin

    LKT Labs

    Borrelidin is a macrolide antibiotic initially produced by Streptomyces. Borrelidin exhibits anti-parasitic, antifungal, anticancer, and anti-angiogenic activities. This compound inhibits threonyl-tRNA synthetase/ligase, inhibiting growth and survival of Trypanosoma, Plasmodium, and Phytophthora.…

  • Alloxan Monohydrate

    LKT Labs

    Alloxan is an oxygenated pyrimidine and toxic analog of glucose. Alloxan destroys ß cells and is used in research models to induce diabetes. This compound does not affect human cells.

  • Caffeic Acid

    LKT Labs

    Caffeic acid is a hydroxycinnamic acid found in coffee, argan oil, Eucaplyptus, Salvinia, and Phellinus; it exhibits antioxidative, anti-diabetic, antibiotic, anti-inflammatory, anti-metastatic, and anticancer activities. Caffeic acid inhibits activity of a-amylase and a-glucosidase. This compound…

  • Caffeine

    LKT Labs

    Caffeine is a xanthine alkaloid found in coffee, tea, and many other plant sources; it exhibits stimulant, bronchodilatory, anti-asthma, vasoconstrictive, anti-inflammatory, antioxidative, anti-aging, and anti-fibrotic activities. Caffeine activates adenosine receptors and inhibits…

  • Acepromazine Maleate

    LKT Labs

  • Azelaic Acid

    LKT Labs

    Azelaic acid is a dicarboxylic acid originally found in Arabidopsis that exhibits anti-inflammatory activity. Azelaic acid is clinically used to treat rosacea, acne, and hyperpigmentary disorders. Azelaic acid directly inhibits kallikrein 5 (KLK5), downregulating expression of KLK5, toll-like…

  • Artesunate

    LKT Labs

    Artesunate is a sesquiterpene lactone derived from Artemisia. Artesunate exhibits anticancer chemotherapeutic, antiviral, anti-angiogenic, and anti-parasitic activities. Artemisinins such as artesunate are best known for their antimalarial activity. Artesunate induces G0/G1 phase cell cycle arrest,…

  • Amygdalin

    LKT Labs

    Amygdalin is a glucoside found in stone fruits and apples that exhibits antinociceptive, analgesic, and anticancer chemotherapeutic activities. In animal models, amygdalin decreases formalin-induced pain. Amygdalin inhibits viability of leukemia cells and induces apoptosis in prostate cancer cells,…

  • Caspofungin Diacetate

    LKT Labs

    Caspofungin acetate is a lipopeptide antifungal that inhibits the enzyme 1,3-ß-Glucan synthase, which synthesizes ß-glucan polymers that form fungal cell walls. Caspofungin acetate is active against a variety of Aspergillus and Candida species and unlike many antifungals, is not metabolized by the…

  • Apigenin

    LKT Labs

    Apigenin is a flavonoid found in various plant sources that exhibits anticancer, antioxidative, anti-inflammatory, cognition enhancing, and neuroprotective activities. In gastric cancer cells, apigenin inhibits cell proliferation, decreases mitochondrial membrane potential, increases expression of…

  • Butylated Hydroxyanisole

    LKT Labs

    Butylated hydroxyanisole (BHA) exhibits antioxidative and anticancer activities. BHA is commercially used as a food additive or preservative, as its free radical scavenging ability stabilizes free radicals and prevents food spoilage. BHS also increases activity of superoxide dismutase (SOD) in…

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