Blasticidin S is used as a selection agent for transformed cells that contain the resistance genes bls, bsr, or BSD. Also used to study protein synthesis at the level of peptide bond formation. Soluble in water PubChem Chemical ID 16760315 Features CAS#: 3513-03-9 Molecular…

Puromycin is an antibiotic of unique structure and biological activity. It is produced by fermentation using Streptomyces albo-niger. There are four aspects of puromycin's biological activity that are 1) antitumor effect; 2) nephrotoxic action; 3) inhibition of purine and/or protein synthesis…

Coelenterazine, native; 2-(p-Hydroxybenzyl)-6-(p-hydroxyphenyl)-8-benzyl-imidazo[1,2-a]pyrazin-3-(7H)-one MOLECULAR BIOLOGY GRADE Coelenterazine is a luminophore found in aquatic organisms and is the substrate for many luciferase enzymes, including Renilla reniformis, Gaussia, and…

Dexamethasone is an anti-inflammatory glucocorticoid that induces the production of phospholipase A2 inhibitory protein (lipocortin). It also inhibits induction of nitric oxide synthase (IC50=5 nM). Dexamethasone has been shown to cause reduction in cyclin A and Cdk2 activity, inhibition of G1/S…

Product Description Antibiotic. Aminopeptidase M, N and leucine and alanine aminopeptidase inhibitor. Potent peptide deformylase (PDF) inhibitor. Inhibits MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-12 and MMP-13, but not MMP-14. Anticancer compound. Antiproliferative. Shows antitumor…

A metabolite with a broad antibiotic spectrum. Inhibitor of mitochonclrial action. K+-selective ionophoric cyclodepsipeptide; potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes…

Antineoplastic antibiotic produced by growth of Streptomyces chrysomallys and other species of Streptomyces. A potent antibiotic that binds to the GpC steps of DNA For in vitro lab use only. Not for human use or consumption. Appearance: Solid Boiling Point: 1386.05 °C at 760…

Actinomycin D is a polypeptide antibiotic first described by Waksman. It is bacteriostatic in nature, especially towards gram negative bacteria, and also has anti-tumor activity. Actinomycin D has a wide-ranging applications ranging from a selection agent in cell culture, use in studies of…

Tobramycin is an aminoglycoside antibiotic derived from Streptomyces tenebrarius and used to treat various types of bacteria infections, particularly Gram-negative infections. It is especially effective against species of Pseudomonas. It works by binding to a site on bacterial 30S and 50S ribosome,…

Paclitaxel has been used as a component of the dechorionation buffer for Gryllus bimaculatus eggs. Paclitaxel has also been used for studying its effect on the movement of all-trans retinoic acid (ATRA) differentiated NB4 cells. Antitumor and antileukemic agent which lowers the critical…

Antibiotic. Antibacterial and antifungal properties. Forms a complex with FKBP12 and inhibits the mammalian target of rapamycin (mTOR). Inhibits the response to interleukin-2 (IL-2), and thereby blocks activation of T and B cells. Potent immunosuppressant used as an alternative to calcineurin…

Oligomycin is a natural antibiotic isolated from Streptomyces diastatochromogenes, which is a mixture of oligomycins A, B, and C. Oligomycin is used as antibiotic which inhibits respiration in mitochondria. It inhibits ATP synthase by blocking its proton channel (F0 subunit), which is necessary…

Bleomycin is a mixture of basic antineoplastic antibiotics produced by glycopeptide produced by Streptomyces verticullus. Bleomycin binds to DNA and causes strand breaks. Bleomycin also inhibits incorporation thymidine into DNA strands. DNA cleavage by bleomycin depends on oxygen and metal ions, at…