A nucleoside reverse transcriptase inhibitor that, following triphosphorylation by thymidine kinase, potently blocks replication of HIV (EC₅₀ = 3 nM) with low cytotoxicity (CC50 > 5 μM).

CAS No.: 528851-31-2 Synonyms: 7-[(2-Aminoethyl)amino]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid hydrochloride Formula: C₁₅H₁₆FN₃O₃ ¬? HCl Formula Weight: 341.77 Linear Formula: …

GSK2578215A is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC₅₀ = 8.9 nM) that also inhibits the G2019S mutant of LRRK2 (IC₅₀ = 10.1 nM). It displays selectivity for LRRK2 over a panel of 460 other kinases. GSK2578215A prevents phosphorylation of both wild-type…

A selective allosteric inhibitor of Bcr-Abl (IC₅₀s = 4.52, 0.38, and 0.93 µM against Bcr-Abl mutants G250E, E255V, and M351T, respectively); displays additive inhibitory activity against T315I Bcr-Abl mutants both in in vitro assays and in a recalcitrant T315I Bcr-Abl mutant mouse…

Synonyms: (1S)-1-(5-(4-(4-((3-Chloropyridin-2-yl)((R)-piperidin-3-yl)carbamoyl)-2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)-1H-tetrazol-1-yl)ethyl ethyl carbonate hydrochloride; Ethyl…

Synonyms: L-ß-HomoPhe(4-CN)-OH·HCl(S)-3-Amino-4-(4-cyanophenyl)butyric acid hydrochloride Purity Limit: ≥ 98% (HPLC) CAS No.: 270065-88-8 Molecular Formula: C11H12N2O2·HCl Molecular Weight: 240.69 MDL No.: MFCD01861078 Appearance: White Powder Melting Point: 212-218 °C …

Synonym: 3α,7α-Dihydroxy-5β-cholanoic acid N-(carboxymethyl)amide sodium salt, Glycochenodeoxycholic acid sodium salt, N-(3α,7α-Dihydroxy-24-oxocholan-24-yl)glycine sodium salt CAS Number: 16564-43-5 Empirical Formula (Hill Notation): …

Synonyms: (R)-1-(3-(4-Amino-3-(4-(3-ethynylphenoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one; Ibrutinib-yne; Probe 4 Molecular Formula: C27H24N6O2 Molecular Weight: 464.52 Linear Structural Formula: C27H24N6O2 Purity: >=98% (HPLC) Storage: room…

Empirical Formula: C₉H₁₂N₂O₅S Linear Formula: C₉H₁₂N₂O₅S Formula Weight: 260.27 MDL Number: MFCD00006538 Purity: ≥98% Storage: −20°C

A metabolite of vinclozolin, a dicarboximide fungicide, that acts as an effective antagonist of the androgen receptor (Ki = 9.7 µM in rat).

N-Acetyl-S-(N’-phenylthiocarbamoyl)-L-cysteine (PITC) is a cysteine conjugate of N-acetyl-phenylisothiocyanate. Isothiocyanates are typically found in plants of the Brassicaceae family, including broccoli, cabbage, and radish. Isothiocyanates are best known for their antioxidative, anticancer…

A cell-permeable analog of cGMP that preferentially activates cGMP-dependent protein kinase; 1 µM-0.1 mM inhibits acetylcholine-induced increases in intracellular calcium concentrations.

A broad-spectrum tetracycline antibiotic which has a particularly long half-life in serum; commonly used in the treatment of acne in older patients; also has both anti-inflammatory and neuroprotective actions.

A selective inhibitor of the TGF-β type1 receptor ALK5 (IC₅₀s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively); used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2…

Synonym: N-[4-[1-Hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide hydrochloride CAS Number: 959-24-0 Empirical Formula (Hill Notation): C₁₂H₂₀N₂O₃S · HCl Molecular Weight: 308.82 EC Number: 213-496-0 MDL Number: …

Synonyms: Actinomycin C₁; Actinomycin IV; Dactinomycin Formula: C₆₂H₈₆N₁₂O₁₆ Formula Weight: 1255.42 CAS No.: 50-76-0 Purity: ≥95% Storage Temperature: 2-8°C Application: Recommended for use in cell culture applications…

Synonyms: 7-Bromo-5-(4-fluorophenyl)-1,3,4,5-tetrahydro-4-(2-iodobenzoyl)-2H-1,4-benzodiazepin-2-one Molecular Formula: C22H15BrFIN2O2 Molecular Weight: 565.17 Linear Structural Formula: C22H15BrFIN2O2 Purity: >=98% (HPLC) Storage: 2-8C Biochem Physiol Actions: SW063058 is…

PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.

An intermediate in the generation of adenine and methionine that is produced by the decarboxylation of SAM; a potent agonist of adenosine receptors (Kis = 0.15, 1.13, 13.9, and 0.68 μM for A1, A2A, A2B, and A3, respectively); inhibits several enzymes at higher concentrations.

An oxidizing reagent that reacts with nitric oxide to form nitric dioxide and corresponding imino nitroxides.

A cell-permeable, fluorescent probe for DNA that is useful as a marker of nuclei for cell cycle studies in combination with BrdU and to distinguish nuclear morphology in apoptotic cells.

ML-204 selectively blocks transient receptor potential canonical 4 (TRPC4) channels (IC₅₀s = 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). It exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5 and does not affect TRPV1,…

A potent and selective CB1 receptor inverse agonist (Ki = 243 nM; EC50 = 195 nM); a 10 µM concentration results in 100% and 35% displacement of [3H]-CP-55,940 at the CB1 and CB2 receptors, respectively.

Synonyms: 4-Hydroxy-1H-indole-6-carboxylic acid Purity Limit: ≥ 98% (HPLC) CAS No.: 40990-52-1 Molecular Formula: C9H7NO3 Molecular Weight: 177.16 MDL No.: MFCD04973988 Appearance: Brown or grey solid Storage Temperature: Store at 0-8°C

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and…

Synonyms: Fmoc-L-Tyr(malonyl-di-OtBu)-OH Purity Limit: ≥ 95% (TLC) CAS No.: 168135-77-1 Molecular Formula: C35H39NO9 Molecular Weight: 617.7 MDL No.: MFCD00672344 Appearance: White powder Storage Temperature: Store at 0-8 °C

Epoxyeicosatrienoic acid (EpETrE; EET) metabolites of arachidonic acid such as 11(12)-EET and 14(15)-EET have been identified as endothelium derived hyperpolarizing factors with vasodilator activity. Soluble epoxide hydrolase (sEH) catalyzes the conversion of EETs to the corresponding dihydroxy…

A cell-permeable, reversible inhibitor of a mitochrondrial glutaminase splice variant, glutaminase C (IC₅₀ = ~2.5 µM), which is commonly found in cancer cells; blocks transformation induced by Rho GTPases and inhibits the proliferation of cancer cell lines without affecting normal cells.

Synonyms: 2-(Pyridin-3-yl)napthalo(-2,3-d)oxazole-4,9-dione Molecular Formula: C16H8N2O3 Molecular Weight: 276.25 Linear Structural Formula: C16H8N2O3 Purity: >=98% (HPLC) Storage: 2-8C Biochem Physiol Actions: potent USP1 inhibitor that induces ID1 degradation,…

Synonyms: Gomisin C; Schizantherin A; Wuweizi ester A Molecular Formula: C30H32O9 Molecular Weight: 536.57 Linear Structural Formula: C30H32O9 Purity: >=98% (HPLC) Storage: -20C Biochem Physiol Actions: Schisantherin A is a mechanism-based inhibitor that competitively…

A small molecule inducer of adult neural stem cell differentiation; 2.5-20 µM triggers neurogenesis and blocks gliogenesis in HCN cells through a neurotransmitter-mediated calcium signal and myocyte-enhancer factor 2-dependent gene expression pathway.

A minor impurity produced in the synthesis of (+)-cloprostenol; 20-fold less active than (+)-cloprostenol in terminating pregnancy in the hamster.