Paclitaxel has been used as a component of the dechorionation buffer for Gryllus bimaculatus eggs. Paclitaxel has also been used for studying its effect on the movement of all-trans retinoic acid (ATRA) differentiated NB4 cells.
Antitumor and antileukemic agent which lowers the critical concentration for tubulin polymerization and reversibly binds to tubulin prohibiting depolymerization; binds to the N-terminal region of beta-tubulin and promotes the formation of highly stable microtubles that resist depolymerization, thus preventing normal cell division and arresting the cell cycle at the G2-M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway in the early phase followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A or of Raf-1 kinase, that results in phosphorylation of Bcl-2.
Purity: ≥98%
Key Applications: Anti-neoplastic agent, Anti-mitotic drug, Antitumor agent, Antileukemic agent
Product Type: Biochemicals
Melting Point: 209 - 219°C
Vapor Pressure: < 1.12 x 10-7 Torr(Lit.)
Presentation: White Powder
Format: Powder
Solubility: Soluble in methanol (50 mg/mL - clear, colorless solution), DMSO (50 mg/mL - clear, colorless solution), chloroform and ethanol.
Storage & Handling: -20°C