Dexamethasone is an anti-inflammatory glucocorticoid that induces the production of phospholipase A2 inhibitory protein (lipocortin). It also inhibits induction of nitric oxide synthase (IC50=5 nM). Dexamethasone has been shown to cause reduction in cyclin A and Cdk2 activity, inhibition of G1/S transition in osteoblasts and inhibition of phosphorylation of Rb protein. Dexamethasone has been observed to induce apoptosis in human thymocytes and eosinophils but to inhibit apoptosis in neutrophils.
Dexamethasone is an anti-inflammatory glucocorticoid with a range of effects on cell survival, cell signaling and gene expression. It is used to study apoptosis, cell signaling pathways and gene expression.
Glucocorticoid is an anti-inflammatory agent. It Regulates T cell survival, growth, and differentiation. It also inhibits the induction of nitric oxide synthase.
Grade: Cell culture reagent
Suitability: Suitable for Cell Culture
Key Applications: Anti-inflammatory
Application Areas: Cell Biology & Analysis
Product Type: Biochemicals
Biochemical Category: Pharmaceuticals
Chemical Class: Pharmaceuticals
Melting Point: 262-264°C(lit.)
Optical Rotation: (c=1, dioxane)+72° to +80°
Refractive Index: 76 ° (C=1, Dioxane) (Lit.)
Presentation: White Powder
Format: Powder
Loss on Drying: ≤0.5%
Solubility: Slightly soluble in water (10 mg/100 mL), ethanol (1 mg/mL), chloroform; sparingly soluble in acetone, alcohol, dioxane, and methanol; very slightly soluble in ether.
Storage & Handling: Store at Room Temperature (15-30°C), protect from light.