Tamoxifen is a Protein Kinase C inhibitor. It induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in…

Dexamethasone is an anti-inflammatory glucocorticoid that induces the production of phospholipase A2 inhibitory protein (lipocortin). It also inhibits induction of nitric oxide synthase (IC50=5 nM). Dexamethasone has been shown to cause reduction in cyclin A and Cdk2 activity, inhibition of G1/S…

Cefsulodin is a third generation cephalosporin antibiotic that has very specific activity against Pseudomonas aeruginosa. It has no significant activity against other Gram-negative bacteria and very limited activity against Gram-positive bacteria and anaerobic bacteria. Cefuslodin is most…

Puromycin is an antibiotic of unique structure and biological activity. It is produced by fermentation using Streptomyces albo-niger. There are four aspects of puromycin's biological activity that are 1) antitumor effect; 2) nephrotoxic action; 3) inhibition of purine and/or protein synthesis…

A metabolite with a broad antibiotic spectrum. Inhibitor of mitochonclrial action. K+-selective ionophoric cyclodepsipeptide; potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes…

Protein Kinase C inhibitor. Tamoxifen Citrate Salt is a nonsteroidal triphenylethylene derivative. Tamoxifen and its metabolite 4-hydroxytamoxifen are mixed estrogen agonists/antagonists. Tamoxifen has been shown to protect bone from estrogen-deficiency bone loss and lower plasma cholesterol in…

Actinomycin D is a polypeptide antibiotic first described by Waksman. It is bacteriostatic in nature, especially towards gram negative bacteria, and also has anti-tumor activity. Actinomycin D has a wide-ranging applications ranging from a selection agent in cell culture, use in studies of…

Tobramycin is an aminoglycoside antibiotic derived from Streptomyces tenebrarius and used to treat various types of bacteria infections, particularly Gram-negative infections. It is especially effective against species of Pseudomonas. It works by binding to a site on bacterial 30S and 50S ribosome,…

Amphotericin B is an antimicrobial/antifungal agent effective against yeast and other fungi. It is a mixture of polyenes. It interrupts cell membrane permeability by binding sterols resulting in the loss of low molecular weight compounds from the cell. Amphotericin B may be toxic to some insect…

Hygromycin B is an antibiotic substance isolated from Streptomyces hygroscopicus. Its mode of action is the inhibition of protein synthesis, by inducing the misreading of the m-RNA template in the prokaryote, (E. coli, at 100 mg/mL), lower eukaryotes (e.g., yeast, at 200 mg/mL) and higher…

Tobramycin is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the Pseudomonas species. Tobramycin has been used: to study the effect of tobramycin on bacteriophage infected biofilms to study…

Paclitaxel has been used as a component of the dechorionation buffer for Gryllus bimaculatus eggs. Paclitaxel has also been used for studying its effect on the movement of all-trans retinoic acid (ATRA) differentiated NB4 cells. Antitumor and antileukemic agent which lowers the critical…

Compound 48/80 is a oligomeric mixture of condensation products from N-methyl-p-methoxyphenethylamine and formaldehyde. It is a mixture of low-molecular weight polymers having a degree of polymerization between 3 to 6. Protein G activator similar to mastoparan. Calmodulin and platelet PLC…