Protein Kinase C inhibitor. Tamoxifen Citrate Salt is a nonsteroidal triphenylethylene derivative. Tamoxifen and its metabolite 4-hydroxytamoxifen are mixed estrogen agonists/antagonists.
Tamoxifen has been shown to protect bone from estrogen-deficiency bone loss and lower plasma cholesterol in the rat. A 10 µM solution has exhibited fungicidal activity (optimal pH 7.5) against yeast cells of C. albicans. It has been implemented in liver carcinogenesis in rats. Other actions of tamoxifen are: Reduction of plasma levels of insulin-like growth factor; Induction of cells surrounding cancer cells to secrete transforming growth factor b; Inhibition of membrane lipid peroxidation probably by decreasing membrane fluidity.
Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells.
Key Applications: Protein kinase C inhibitor, Induces apoptosis, Mixed estrogen agonists/antagonists
Application Areas: Molecular biology
Product Type: Biochemicals
Chemical Class: Pharmaceuticals
Presentation: White Powder
Format: Powder
pKa: approximately 8.854; approximately 6.9 (in Triton® X-100)(Lit.)
Solubility: Soluble in methanol (50 mg/mL with heat) or ethanol (10 mg/mL with sonication); very slightly soluble in water (0.3 mg/L at 20°C; the pH is approximately 3.0-3.5), 0.02 N HCl (0.2 mg/mL at 37°C), acetone or chloroform.
Storage & Handling: Store at +4°C. Store desiccated. Protect from light.