Cayman Chemical

An analog of the PKC-activating second messenger diacylglycerol; activates PKC 15% at 25 µM.

An analog of (−)-blebbistatin that is stable to prolonged irradiation at 450-490 nm and has been successfully used in fluorescent live cell imaging.

A fungal metabolite that inhibits cyclooxygenase, blocking both the conversion of AA to PGH2 and the conversion of PGH2 to PGE2 (IC₅₀s = 40 and 9 µM, respectively); also inhibits the reverse transcriptase of avian myeloblastosis virus, bacterial transglycosylases, and telomerase...

A plant growth regulator involved in the signaling mechanisms for a variety of conditions including plant defense, wound healing, tuberization, fruit ripening, and senescence.

Potently induces HIV-1 reactivation in latent reservoirs of infected Jurkat-LAT-GFP cells (IC50 = ~0.5 µM); activates NF-κB via PKC and downregulates HIV-1 receptor CD4 expression and its co-receptors CXCR4 and CCR5.

An intermediate in the interconversion of glucose and galactose.

A CAAX peptidomimetic that selectively inhibits geranylgeranyltransferase I; arrests human tumor cells (IC₅₀ = 10 µM for A549 cells) in G0/G1 and induces apoptosis by inhibiting proteasome activity and up-regulating the expression of the cyclin-dependent kinase inhibitor p21.

An enantiomer of pramipexole that is ~100-fold less active than the (S) form as a dopamine receptor agonist; an antioxidant that targets mitochondria to prevent apoptosis.

A potent agonist of the serotonin 4 receptor (5-HT4, Ki = 3.9-31 nM; also acts as an antagonist for the 5-HT2A, 5-HT2B, and 5-HT2C receptors (Ki = 32, 3.9, and 100 nM, respectively); stimulates colonic motility and transit in vivo.

An allosteric, reversible inhibitor of PAR1 on platelets, preventing surface expression of P-selectin induced by the peptide SFLLRN with an IC₅₀ value of 0.26 µM; also blocks platelet activation induced by thrombin but not by PMA, U-46619, or collagen.

First metabolite of PGF2α in the 15-hydroxy PGDH pathway; a critical component in the goldfish and Atlantic salmon postovulatory pheromone.

A caspase-independent (nonapoptotic) cell death inducer; inhibits FLT3 (IC₅₀ = 0.34 µM) and DYRK1A and DYRK2 (IC₅₀s = 1.9 and 1.3 µM, respectively); also inhibits Aurora B and C kinases (IC₅₀s = 4.6 and 0.7 µM, respectively).

A nucleoside analog inhibits polyadenylation when converted to cordycepin triphosphate, which inhibits ATP-dependent DNA and RNA synthesis; produces anti-proliferative, pro-apoptotic, and anti-inflammatory effects.

A synthetic intermediate useful for pharmaceutical synthesis.

Contains four deuterium atoms at the 3', 3', 4', and 4' positions; is intended for use as an internal standard for the quantification of tafluprost (free acid) by GC-or LC-mass spectrometry.

A potent, selective antagonist of ETB (IC₅₀ = 1.2 nM for blocking ET-1 binding to human Girardi heart cells); competitively antagonizes the vasoconstriction induced by an ETB-selective agonist on isolated rabbit pulmonary arteries.

A specific Akt inhibitor that has been shown to inhibit proliferation and to induce apoptosis of thyroid cancer cells (IC₅₀ = 30-60 nM in vitro); inhibits Akt, PDK1, and FLT3 in acute myelogenous leukemia cells, decreasing the colony-forming ability of these cells (IC₅₀<200... <>

A general inhibitor of DUBs, significantly reducing the activity of a panel of DUBs with EC₅₀ values ranging from 5-20 µM; cell-permeable and reversible in its action.

An activator of Ca2+-sensitive K+ channels (EC₅₀ = 490 µM in T84 human carcinoma cells); also activates the human intermediate conductance Ca2+-activated K+ channel (EC₅₀ = 74 µM).

A conventional antipsychotic drug that potently activates several neuroreceptors, including serotonin (Kis = 10, 60, and 57 nM for 5-HT2A, 5-HT2C, and 5-HT6, respectively), dopamine D2 (Ki = 11 nM), and adrenergic α1A (Ki = 5 nM) receptors; has efficacy in drug resistant tuberculosis.

An intermediate in the catabolism of aromatic amino acids; formed in excess during alkaptonuria.

An aryl-benzoyl-imidazole which prevents proliferation of multidrug resistant cancer cells in vitro (IC50 = 28-63 nM) and inhibits melanoma xenograph tumor growth in vivo (10-30 mg/kg); binds to tubulin (Ki = 3.4 μM) and prevents tubulin polymerization.

(±)15-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 15(S)-HEPE and 15(R)-HEPE. Specific biological activity attributed to (±)15-HEPE has not been documented.

A 1,4-naphthoquinone that acts as a redox-cycling agent, typically increasing intracellular superoxide and hydrogen peroxide formation.