Cayman Chemical

A substrate for polyamine oxidase that is oxidized to 3-acetamidopropanal and putrescine, a polyamine involved in the division, differentiation, and membrane function of cells; used to examine the interaction between DNA and polyamines during the cleavage of phosphodiester bonds at...

Source: Recombinant N-terminal GST-tagged protein expressed in E. coli Mr: 41.2 kDa BRDT shares homology with the RING3 protein. The two bromodomains of BRDT recognize acetylated histone H4. Loss of BRDT leads to defects in spermatogenesis. In addition to testis specific expression, BRDT was found...

An inhibitor of PLC-dependent processes by an undefined mechanism; inhibits platelet aggregation induced by collagen or thrombin with IC₅₀ values of 0.6 and 5 µM, respectively.

15-OxoEDE is produced by the oxidation of 15-HEDE. 15-oxoEDE inhibits 5-LO from RBL-1 cells with an IC₅₀ of 55 µM, which is about 2-fold lower than 15(S)-HEDE. A related oxo-eicosanoid, 5-oxoETE, is biosynthesized from 5(S)-HETE by a specific dehydrogenase and has potent...

An analog of the nucleoside adenosine that has antiviral properties; acts as a prodrug that, once phosphorylated by cellular enzymes, acts as both substrate and inhibitor of DNA polymerase.

An inactive stereoisomer (IC₅₀ ≥ 1 mM) of the Cdk5 inhibitor olomoucine; may have utility as a control compound for determining Cdk5 specificity; rapidly inhibits dopamine transporter activity in rat dorsal striatal synaptosomes with an IC₅₀ value of ~37 μM.

A long-chain N-acylated HSL that functions as a quorum sensing signaling molecule.

A pan tyrosine kinase inhibitor that primarily targets VEGFR2 (IC₅₀ = 0.035 nM) and c-Met (IC₅₀ = 1.3 nM) but also inhibits RET, c-Kit, AXL, FLT3, and Tie2 (IC₅₀ = 5.2, 4.6, 7, 11.3, and 14.3 nM, respectively); reduces tumor and endothelial cell proliferation,...

A potent, selective, orally bioavailable inhibitor of ACAT-1 (IC₅₀ = 73 nM).

A pentavalent antimony derivative that is highly active against Leishmania amastigotes in macrophages.

A hydroxylated metabolite of estrone as well as an interconversion product with estriol; formed by CYP1A1, CYP3A5, CYP3A4, and CYP3A7; binds covalently and persistently activates estrogen receptors; increases cell proliferation and does not suppress TNF-α secretion.

A methyl ester prodrug form of the NOS inhibitor L-NNA; exhibits Ki values of 15 nM, 39 nM, and 4.4 µM for nNOS (bovine), eNOS (human), and iNOS (mouse), respectively.

Antigen: human Host: rabbit Cross Reactivity: (-) Non-citrullinated histone H1 Species Reactivity: (+) human Application(s): WB

A member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids.

Antigen: purified ovine COX-1 Host: mouse, clone CX111 Cross-Reactivity: (+) human, bovine, mouse, ovine, and rat COX-1, human COX-2 (~5%), ovine COX-2 (50%); (−) mouse COX-2 Application(s): FC and IF Isotype: IgG2b This product is derived by labeling the COX-1 monoclonal antibody (Item No....

WS3 is a non-specific proliferative molecule that modulates the activity of Erb3 binding protein-1 and the IκB kinase pathway. It has been used to mediate proliferation of primary retinal pigment epithelial cells ex vivo in order to provide a renewable source of cells for transplantation in a...

Peptide Sequence: human COX-2 amino acids 567-599 (SVPDPELIKTVTINASSSRSGLDDINPTVLLKE) To be used in conjunction with Cayman’s COX-2 (human) polyclonal antibody (Catalog No. 160107) or the COX-2 (human) monoclonal antibodies (Catalog Nos. 160112, 160113, and 160122) to block protein-antibody...

8-Bromoisoquinoline is a synthetic intermediate useful for pharmaceutical synthesis.

ω-3 Arachidonic acid is a rare PUFA found in trace amounts in dietary sources. ω-3 Fatty acids are known to be essential for infant growth and development and they protect against heart disease, thrombosis, hypertension, as well as inflammatory and autoimmune disorders. In human platelet...

A fluorinated pyrimidine and derivative of fluorouracil that has anti-neoplastic activity and is commonly used as adjuvant therapy following resection for some forms of cancer; a potent inhibitor of acid ceramidase (IC₅₀ = 29 nM).

A potent, time-dependent, irreversible FAAH inhibitor with IC50 values of 0.99 and 0.333 µM when preincubated with human recombinant FAAH for 5 and 60 minutes, respectively.

An isomer of LTB4 which would not be expected to occur in either non-enzymatic hydrolysis products, or in the enzymatic products of LTA4 hydrolase; has significantly reduced activity compared to LTB4.

An inhibitor of fatty acid synthesis that blocks the synthesis of malonyl-CoA by acetyl-CoA carboxylase (ACC).

CB-5083 is an orally bioavailable inhibitor of p97 (IC₅₀ = 11 nM), a transitional endoplasmic reticulum ATPase also known as valosin-containing protein (VCP). It disrupts cellular protein homeostasis and demonstrates anti-tumor activity in hematological and solid tumor models. CB-5083...