Cayman Chemical

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human retinoid X receptor beta (NR2B2), a ligand-dependent transcription factor commonly referred to as RXRB or RXRβ. INDIGO’s reporter cells include...

A third generation inhibitor of p38 MAP kinases, binding to both p38α and p38β (Kd = 3.7 and 17 nM, respectively); inhibits IL-6, IL-1β, and TNF-α production in LPS-primed blood with IC50 values of 59, 122, and 99 ng/ml, respectively.

A methylxanthine bronchodilator that inhibits phosphodiesterase activity and, thus, increases cAMP; demonstrates decreased affinity towards adenosine A1 and A2 receptors, does not interfere with calcium influx into cells, and does not antagonize the action of calcium-channel blockers.

A potent inhibitor of FAAH, with an IC₅₀ of 9.1 nM; also inhibits MAGL at ~1,000-fold higher concentration (IC₅₀ = 7.9 μM).

A non-competitive NMDA receptor antagonist that inhibits neuronal calcium channel currents; selective for NR2B subunit-containing receptors (IC₅₀ = 1 µM), displaying greater than 100-fold selectivity for NR2B over NR2A and NR2C subunits.

A nonaminoglycoside that has been reported to selectively induce ribosomes to read through premature nonsense stop signals on mRNA, thus allowing the production of full-length, functional proteins (IC₅₀ = 7 nM); 60 mg/kg s.c. injection or 0.3-0.9 mg/ml orally has been shown to restore...

Antigen: mouse/rat COX-2 amino acids 570-598 Host: rabbit Cross-Reactivity: (+) human, guinea pig, monkey, mouse, ovine, rabbit, and rat COX-2; (−) COX-1 (all species) Application(s): ICC, IHC, and WB

An internal standard for the quantification of N-arachidonoyl-L-serine by GC- or LC-MS.

A synthetic analog of fumagillin that inhibits angiogenesis; irreversibly inactivates methionine aminopeptidase-2 (IC₅₀ = 2 µM), blocking endothelial cell proliferation in vitro and angiogenesis in vivo.

A potent inhibitor of class I PI3K isoforms (IC₅₀ values of 5, 27, 7, and 14 nM for PI3Kα, β, δ, and γ, respectively) and mTOR (Ki = 17 nM); induces cell cycle arrest or apoptosis in a range of cancer cell lines; effective in vivo, suppressing the growth of a number...

An active, estrogenic metabolite of daidzein; has vasodilatory action on rat isolated aortic rings at 1 µg/ml; stimulates the estrogen receptor-dependent growth of breast cancer MCF-7 cells at micromolar concentrations.

A substrate for alkaline phosphatase that can be used in enzymatic reactions to quantify ALP activity.

A long-chain fatty acid that exists naturally as a triglyceride in canola, peanut, and marine animal oils as well as animal milk fats and peanut skins.

LTD4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. LTD4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity. LTD4 is...

A cell-permeable benzylidene rhodamine that inhibits PRL-3 (IC₅₀ = 900 nM for human PRL-3 in vitro), with minimal activity against other phosphatases; reduces the invasion of mouse melanoma B16F10 cells in a cell-based assay.

A pyridine-containing tetracycle that interferes with JAK kinase activity interacting within the ATP-binding cleft (IC₅₀s = 15, 1, and 5 nM for JAK1, 2, and 3, respectively); block IL-2 and IL-4-dependent proliferation of mouse T-cell lymphoma cells (IC₅₀s = 50-100 nM).

A non-selective NSAID exhibiting IC50 values of 0.5 and 2.33 µM for human recombinant COX-1 and COX-2, respectively.

A prodrug for mycophenolic acid, an inhibitor of inosine monophosphate dehydrogenase; blocks de novo GTP generation as well as RNA and DNA synthesis; inhibits lymphocyte proliferation and activation; used to benefit organ transplantation as well as autoimmunological diseases like lupus.

A form of 17-phenyl trinor PGF modified with a cyclohexane moiety at the alpha carbon; insoluble in aqueous media, soluble in organic solvents; activity at the FP receptor has not been evaluated.

A selective α2-adrenergic receptor agonist (Ki = 183 nM) that lowers intraocular pressure by decreasing aqueous humor synthesis and increasing drainage through uveoscleral outflow; protects rat retinal ganglion cells against glutamate excitotoxicity by inhibiting glutamate release and blocking...

A highly selective, non-ATP competitive inhibitor of p38/mitogen-activated protein kinase-activated protein kinase 2 (IC₅₀ = 0.11 μM); inhibits TNF-α (IC₅₀ = 4.4 μM) and IL-6 (IC₅₀ = 5.2 μM) secretion from the human THP-1 acute monocytic leukemia cell...

8-iso PGF1α is an isoprostane that was first identified in human semen. It is a member of the isoprostane family, which are eicosanoids of non-cyclooxygenase origin. 8-iso PGF1α is present along with its 19-hydroxy congener at 5-10 µg/ml of seminal plasma.

SE 175 is an organic nitrate compound of the same general class as nitroglycerin. These nitrate compounds can act as NO-donors in vivo following reductive transformation of the nitrate group to nitric oxide. The nitroxyacylated thiosalicylates, such as SE 175, were developed in an effort to...

A metabolite of dimetridazole, the nitroimidazole-based antibacterial and anticoccidial agent suspected to be carcinogenic and mutagenic to humans.