A potent inhibitor of class I PI3K isoforms (IC50 values of 5, 27, 7, and 14 nM for PI3Kα, β, δ, and γ, respectively) and mTOR (Ki = 17 nM); induces cell cycle arrest or apoptosis in a range of cancer cell lines; effective in vivo, suppressing the growth of a number of tumor xenografts in mice.