Cayman Chemical

Increases the activity of angiotensin-converting enzyme 2 (ACE2) in vitro (EC50 = 19.5 μM).

An HDAC inhibitor that increases histone H3 acetylation levels in LoVo and HT-29 colon cancer cells at concentrations as low as 4 µM; dose-dependently decreases the activation of several oncogenic signaling kinases and induces cell cycle arrest in colon cancer cells.

Immunogen: synthetic peptide from the N-terminal region of human H-PGDS Host: rabbit Species Reactivity: (+) human, baboon, mouse, and rat H-PGDS Application(s): WB

Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser58 of TPH Host: rabbit Cross Reactivity: (+) rabbit TPH; expected to react with bovine, canine, human, mouse, non-human primate, rat, Xenopus, and zebrafish TPH Application: WB

A glutathione derivative endogenous to mammalian cells that is comprised of the oxidized form of free glutathione tripeptide linked via a disulfide bond to L-cysteine; protects mice against acetaminophen-induced hepatotoxicity.

A potent, allosteric inhibitor of Akt1 and Akt2 (IC₅₀ = 58 and 210 nM, respectively) that less effectively blocks Akt3 activity (IC₅₀ = 2.2 µM); cell permeable, blocking insulin regulation of FOXO1 activity at 1 µM in rat hepatoma cells.

A dual inhibitor of COX and LOX pathways, that decreases levels of PGE2, LTB4, and lipoxins and prevents LPS-stimulated IL-1β expression.

An antibiotic and antitumor compound that acts as an inhibitor of XMP aminase (IC₅₀ = 67 µM).

A selective JAK3 inhibitor (Ki = 2.5 nM; IC₅₀ = 50-170 nM); reduces proinflammatory responses in a rat collagen-induced arthritis model and a mouse model of oxazolone-induced delayed-type hypersensitivity.

Source: Active recombinant N-terminal His-tagged protein expressed in E. coli MW: 75.8 kDa PAD4 is a homodimer that functions as a transcriptional coregulator to catalyze the conversion of specific arginine residues to citrulline in a calcium-dependent manner. PAD4 substrates include histones H2A,...

A marine sponge alkaloid that inhibits Chk1 and Chk2 (IC₅₀ = 3 and 3.5 µM, respectively), blocking G2 arrest; also inhibits MEK-1 (IC₅₀ = 881 nM), GSK3β (IC₅₀ = 1.39 μM), Cdk5/p25 (IC₅₀ = 9.12 &

11-trans LTC4 is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-trans LTC4 during storage. 11-trans LTC4 is produced in smaller amounts relative to LTC4 in ionophore-stimulated HMC-1 cells (a human mast cell line) and equine eosinophils, but not in...

A highly selective open channel blocker that targets If carried by HCN channels; suppresses channel activity at HCN1, HCN2, and HCN4, all with the same EC₅₀ value of 4 µM; selectively targets cardiac signaling, resulting in resting heart rate reducing (bradycardic) effects.

D(−)-Lactate is a stereoisomer of lactate and is present in blood at only 1-5% the concentration of L(+)-lactate. Exogenous sources of D-lactate include fermented foods such as yogurt, sauerkraut, and pickles. D-lactate is normally produced in the gastrointestinal tract, mainly by lactobacilli...

A first generation inhibitor of the HIV-1 aspartic protease (Ki = 0.04 nM) that blocks replication of HIV-1 in the human T cell MT-4 cell line (IC₅₀ = 150 nM) as well as in peripheral blood lymphocytes (IC₅₀ = 80 nM).

A cell-permeable, irreversible pan-caspase inhibitor; contains a methyl ester group, which facilitates uptake by cells and subsequently is removed by cytoplasmic esterases, leaving the functional inhibitor.

Inhibits the p53-Mdm2 interaction (Ki = 83 nM) and also dose-dependently reduces activation of the NF-κB pathway; prevents phosphorylation of IκBα by IKKα, IKKβ, and IKKE (IC₅₀s = 80.5, 78.2, and 57.1 µM, respectively); inhibits the growth of A549 cell...

A natural product with diverse therapeutic effects, including acting as an anxiolytic in mice; inhibits NF-κB and PI3K/Akt signaling, preventing inflammation; interferes with angiogenesis while preventing tumor growth in vivo; scavenges superoxide and peroxyl radicals.

A phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC₅₀ = 92 nM); effective in vitro and in vivo.

Antigen: human CysLT2 receptor C-terminal amino acids 330-346 Host: rabbit Cross Reactivity: (+) human CysLT2 receptor; (−) CysLT1 receptor, mouse, ovine, and rat CysLT2 receptors Application(s): ELISA, FC, IHC, and WB The CysLT2 receptor binds LTD4, LTC4, and LTE4 playing a major role in...

A selective cholesterol transport inhibitor that targets the NPC1L1 (KDs = 12,000, 540, 40, and 220 nM for its glucuronide in mouse, rat, rhesus monkey, and human, respectively); blocks intestinal cholesterol absorption in various animal models (IC₅₀s = 0.0005-0.05 mg/kg).

A non-specific β-adrenergic blocker with affinity for both β1 and β2-adrenergic receptors; acts as a potent β-adrenoceptor antagonist with partial agonist activity; metabolized by CYP2D6, CYP1A2, and CYP2C19.

A natural red bacterial pigment that has antibiotic, antitumor, and immunosuppressant properties; blocks T cell proliferation at a concentration of 30 ng/ml, by interfering with IL-2 receptor expression; induces apoptosis in cancer cells by diverse mechanisms and rescues deficient p53 signaling.

A potent and selective inhibitor of PDGF receptor kinase with an IC50 value of about 0.4 µM both in vitro and in cells (Swiss 3T3 cells).