Source: Active recombinant N-terminal His-tagged protein expressed in E. coli
MW: 75.8 kDa
PAD4 is a homodimer that functions as a transcriptional coregulator to catalyze the conversion of specific arginine residues to citrulline in a calcium-dependent manner. PAD4 substrates include histones H2A, H3, and H4, whose post-translational modifications play a large role in gene regulation.