Cayman Chemical

A non-steroidal androgen receptor antagonist (IC50 = 36 nM); reduces the efficiency of nuclear translocation of the androgen receptor and impairs both its binding to DNA and the recruitment of coactivators.

A reversible, competitive thrombin inhibitor (Ki = 5 nM) that shows selectivity for thrombin over other clotting pathway enzymes.

AFC is a synthetic substrate for the isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). Because it is able to serve as a substrate for the methyltransferase, it effectively functions as an inhibitor of methylation of endogenous isoprenylated...

A NSAID that inhibits COX-1 and -2 activity with IC₅₀ values of 17.4 and 13.1 µM, respectively.

A synthetic peptide that contains the sequence PVPPR, which corresponds to a region within human Sos1 that interacts with an SH3 domain of Grb2; specifically blocks the interaction of Sos1 with Grb2, preventing an interaction that is essential for Ras activation by receptor tyrosine kinases.

Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a ubiquitously expressed, basic leucine zipper transcription factor. It regulates the expression of a variety of genes,encoding proteins that play critical roles in cyto-protection, as well as the detoxification and clearance of harmful...

An internal standard for the quantification of PGE1 by GC- or LC-MS.

An FGF inhibitor.

An analog of calcitriol that, like calcitriol, is a receptor-active form of vitamin D3 which effectively blocks PTH synthesis; inhibits human keratinocyte proliferation and is beneficial in treating psoriasis; blocks the proliferation while inducing differentiation and apoptosis of certain tumor...

A non-ATP competitive inhibitor of GSK3β (IC₅₀ = 2 µM) that binds to the active site of GSK3β; used to study the role of GSK-3β during stem cell differentiation as well as in cell and animal models of Alzheimer’s disease and other neurodegenerative disorders.

Host: mouse, clone 203.6 Cross Reactivity: (+) human CD27 Application(s): FC, ICC, and IHC (frozen sections); (−) WB

Cayman’s Protein Synthesis Assay Kit is a non-radioactive method for measuring protein synthesis that employs the cell-permeable, alkyne-containing, puromycin analog O-Propargyl-puromycin (OPP). Upon application to cells, the OPP probe incorporates into the C-terminus of translating...

ZCL 278 is a cell-permeable inhibitor of Cdc42, a Rho family GTPase. It binds into the surface groove on Cdc42 (K_d = 6.4-11.4 µM), blocking interaction with intersectin (ITSN), a guanine nucleotide exchange factor (GEF). It inhibits Cdc42-mediated microspike formation and neuronal...

A cell-penetrating peptide inhibitor of calpain (IC₅₀ = 5 nM) which completely abolishes calpain activity in platelets; also a potent inhibitor of cathepsin K (IC₅₀ = 0.11 nM).

AZ 5104 is an active, demethylated metabolite of AZD 9291 (Item No. 16237), an irreversible inhibitor of EGFR-sensitizing and T790M resistance mutations (IC₅₀s = 15-17 nM) that spares the wild-type form of the receptor (IC₅₀ = 480 nM). AZ 5104 displays a similar overall...

An inhibitor of serine proteases that dose-dependently inhibits trypsin from a variety of sources, as well as plasma kallikrein, thrombin, plasmin, and other serine proteases; partially inhibits chymotrypsin and neutrophil elastase.

A more lipid-soluble form of DPA amenable to analysis using gas chromatography; may serve as a prodrug, since it should facilitate uptake of DPA and then be hydrolyzed by esterases to generate the free acid after uptake into cells.

A natural coumarin that binds iron; inhibits aldose reductase activity in galactose-fed rats, upregulates PPARγ expression, and triggers phosphorylation of Nrf2 in animals.

A prodrug that is rapidly catabolized in vivo to 5-fluorouracil when administered by rapid injection; inhibits thymidylate synthase (EC₅₀ = 0.6 nM), interfering with DNA synthesis; used to treat various cancers, particularly metastases to the liver.

A synthetic intermediate useful for pharmaceutical synthesis.

A form of the myristic acid that is found in the lipid A component of some Gram negative bacteria, including Escherichia, Haemophilus, Actinobacillus, and Campylobacter species.

A potent, cell-permeable, and irreversible inhibitor of all Cdc25 isoforms, with preference for Cdc25A (IC₅₀ = 29, 95, and 89 nM for Cdc25A, Cdc25B2, and Cdc25C, respectively); arrests cells at both G1 and G2/M phases and prevents the proliferation of several human tumor cell lines.

A metabolite of vinclozolin, a dicarboximide fungicide, that acts as an effective antagonist of the androgen receptor (Ki = 9.7 µM in rat).

Antigen: native bovine ubiquitin conjugated to KLH Host: rabbit Cross Reactivity: (+) human, monkey, mouse, rat, hamster, rabbit, guinea pig, bovine, porcine, canine, pvine, chicken, Xenopus, yeast, Drosophila, and Rainbow Trout ubiquitin Application(s): WB, IP, and ChIP Ubiquitin functions to clear...