Synonym: N-[3-[[2-Methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-1H-indol-5-yl]carbamic acid cyclopentyl ester
CAS Number: 107753-78-6
Empirical Formula (Hill Notation): C31H33N3O6S
Molecular Weight: 575.68
MDL Number: MFCD00864775
Biochem/physiol Actions
Zafirlukast is a potent subtype specific cysteinyl leukotriene type 1 receptor (CysLT1) antagonist; antiasthmatic. Zafirlukast has over 1000-fold selectivity for CysLT1, one of two receptors for cysteinyl leukotrienes LTC4, LTD4, and LTE4, which are important mediators of human bronchial asthma.
Features and Benefits
This compound is featured on the Leukotriene Receptors page of the Handbook of Receptor Classification and Signal Transduction.
This compound was developed by AstraZeneca.
Assay: ≥98% (HPLC)
Form: solid
Solubility: DMSO: ≥28 mg/mL
Originator: AstraZeneca
Storage Temp.: room temp