Yu Fluorination Ligand is widely employed for the chemoselective functionalization of sp2- and sp3 C-H bonds.
Synonyms: 2,5,6,8-tetramethyl-3,4-dihydro-2H-pyrano[2,3-b]quinoline
Molecular Formula: C16H19NO
Molecular Weight: 241.33
Linear Structural Formula: C16H19NO
Purity: >=95%
Application: The Yu Fluorination Ligand in tandem with Selectfluor(R) (Aldrich 439479) under palladium catalysis can promote direct fluorination of C(sp3)-H bonds stereoselectively. Yu and coworkers have displayed this on amino acid derivatives with directing group assistance from the Yu-Wasa Auxiliary (Aldrich 791806).