Yoda1 is a novel synthetic small molecule developed to study the kinetics, regulation and function of the cation channel Piezo-type mechanosensitive ion channel component 1 (Piezo1).
Synonyms: 2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]-pyrazine
Molecular Formula: C13H8Cl2N4S2
Molecular Weight: 355.27
Linear Structural Formula: C13H8Cl2N4S2
Purity: >=98% (HPLC)
Storage: 2-8C
Application: Yoda1 has been used to investigate its effect on heterotrimeric Piezo1 channels.
Biochem Physiol Actions: Yoda1 is a specific activator of mouse and human cation channel Piezo1, a mechanosensitive channel that mediates Ca2+ influx on mechanical activation and has been linked to a role in blood vessel development. Yoda1 stabilizes the Piezo1 open channel. In red blood cells, this was followed by downstream activation of the KCa3.1 Gardos channel with resultant calcium influx and potassium and water efflux, causing shrinkage of the cells. Yoda1 is the first Piezo1 agonist, giving the first evidence of non-mechanical activation of a Piezo channel.