Synonyms: N-[2-[4-[[[2-[(Hydroxyamino)carbonyl]-4,6-dimethylphenyl](phenylmethyl)amino]sulfonyl]phenoxy]ethyl]-2-benzofurancarboxamide; WAY170523
Molecular Formula: C33H31N3O7S
Molecular Weight: 613.68
Linear Structural Formula: C33H31N3O7S
MDL Number: MFCD09753279
Purity: >=98% (HPLC)
Storage: room temp
Biochem Physiol Actions: WAY 170523 is a potent and selective inhibitor of matrix metalloprotease MMP-13 (Collagenase-3), expressed in the skeleton during embryonic development, and sometimes highly overexpressed in human carcinomas and in chondrocytes and synovial cells in rheumatoid arthritis and osteoarthritis. Mutations in the MMP-13 gene has been shown to cause metaphyseal anadysplasia (MANDP). WAY 170523 has an IC50 of 17 nM for MMP-13 and showed >5800-, 56-, and >500-fold selectivity against MMP-1, MMP-9, and TACE (TNFa converting enzyme), respectively.
Legal Information: Sold for research purposes under agreement from Pfizer Inc.