Synonyms: (Hydroxy-bis(trimethylsilyl)silyl)-trimethylsilane; (TMS)3SiOH; 1,1,1,3,3,3-Hexamethyl-2-(trimethylsilyl)trisilan-2-ol; Supersilanol
Molecular Formula: C9H28OSi4
Molecular Weight: 264.66
Linear Structural Formula: C9H28OSi4
MDL Number: MFCD00093727
Purity: >=95%
Density: 0.859 g/mL
Refractive Index: n/D 1.496
Application: Under a dual catalytic copper/photoredox manifold, this supersilanol has been demonstrated by the MacMillan lab to be an excellent reagent for the trifluoromethylation of alkyl halides and aryl halides to yield alkyl-CF3 and aryl-CF3 in high yields. In both cases, these reactions exhibit wide substrate scope with good functional group tolerance. More specifically, a variety of 5-membered and 6-membered heteroaryl halides can be readily converted to the corresponding trifluoromethylheteroarenes under mild conditions. To be use in conjunction with dMesSCF3 (901466) and Ir photocatalyst (902217 or 902225).
Other Notes: A radical approach to the copper oxidative addition problem: Trifluoromethylation of bromoarenes