This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Synonyms: PG 490
Molecular Formula: C20H24O6
Molecular Weight: 360.4
Linear Structural Formula: C20H24O6
MDL Number: MFCD00210565
Purity: >=98.0% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: Triptolide is a diterpene triepoxide, the principal active ingredient in extracts from the Chinese herb Tripterygium wilfordii hook (TwHF). It is a potent immunosuppressant and anti-inflammatory. Triptolide has been shown to inhibit the expression of IL-2 in activated T cells at the level of purine-box/nuclear factor and NF-kappaB mediated transcription activation. It synergizes with cyclosporin A in promoting graft survival in animal models and in suppression of graft versus host disease in allogeneic bone marrow transplants. In addition, it induces apoptosis in tumor cells and potentiates tumor necrosis factor (TNFalpha) induction of apoptosis in part through the suppression of c-IAP2 and c-IAP1 induction.
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