Synonyms: 2,4,7-Undecatrienal nitrosohydrazone; WS1228A
CAS Number: 76896-80-5
Formula: C11H17N3O
Formula Weight: 207.27
Linear Formula: C11H17N3O
MDL No.: MFCD00798237
Storage: -20C
UNSPSC Code: 12352200
General description: Triacsin C belongs to a family of fungal metabolites all having an 11-carbon alkenyl chain with a common N-hydroxytriazene moiety at the terminus.
Application: Triacsin C was found to induce maturation in mouse and Xenopus oocytes in the absence of long-chain acyl-CoA synthetase. Triacsin C can also block palmitoylation of the G-protein alpha S subunit6. Furthermore, triacsin C can stabilize1-oleoyl-2-acetyl-sn-glycerol (OAG) and enhance perilipin 3 recruitment to the endoplasmic reticulum (ER) in mouse cells7.
Biochem/physiol Actions: Triacsin C is a potent inhibitor of long-chain fatty acyl CoA synthetase. It blocks beta-cell apoptosis, induced by fatty acids (lipoapoptosis) in a rat model of obesity. In addition, it blocks the de novo synthesis of triglycerides, diglycerides, and cholesterol esters, thus interfering with lipid metabolism.
Preparation Note: Triacsin C is soluble in methanol at 4.90 - 5.10 mg/ml and yields a clear, pale yellow to yellow solution.
RIDADR: NONH for all modes of transport
WGK Germany: 3