Synonyms: Cyclo((S)-phenylalanyl-(S)-phenylalanyl-(R)-pipecolinyl-(2S,9S)-2-amino-8-oxo-9,10-epoxydecanoyl); RF 1023A
CAS Number: 133155-89-2
Formula: C34H42N4O6
Formula Weight: 602.72
Linear Formula: C34H42N4O6
Purity: >=98% (HPLC)
Storage: -20C
UNSPSC Code: 12352200
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Biochem/physiol Actions: Trapoxin A is a cyclotetrapeptide and a histone deacetylase (HDAC) inhibitor. It increases the level of chromatin acetylation associated with histone H3 at low nanomolar concentrations. Unlike the reversible HDAC inhibition induced by TCA, Trapoxin A irreversibly inhibites HDAC activity in crude cell lysates, and induces the accumulation of hyperacetylated core histones in a number of mammalian cell lines and tissues. Histone acetylation and methylation have been studied extensively for their anti-tumor activities in carcinogenesis and Trapoxin has been suggested as a potential anticancer agent for pre-clinical trials.
Preparation Note: Trapoxin A is soluble in DMSO at a concentration ranging from 0.9-1.10 mg/ml and yields a clear, colorless to faint yellow solution. It is also soluble in chloroform and methanol.
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
R Codes: 25
S Codes: 45
IOD Codes: T
Symbol: GHS06
Signal Word: Danger
Hazard Statements: H301
Precautionary statements: P301 + P310