Antigen: fusion protein corresponding to amino acids 77-186 of human TRAF5
Host: mouse
Cross Reactivity: (+) human and mouse TRAF5
Application(s): WB
TRAF5, an adaptor protein that mediates signal transduction from TNF receptors, is implicated in NF-kB and c-Jun NH(2)-terminal kinase/stress-activated protein kinase activation by members of the TNF receptor superfamily, including CD27, CD30, CD40, and lymphotoxin-β receptor. Targeted disruption of TRAF5 gene causes defects in CD40-CD27 mediated lymphocyte activation.