Thrombopoietin (TPO) is a glycoprotein hormone which belongs to the EPO/TPO family. It produced by the liver and kidney which regulates the production of platelets. TPO stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. Lineage-specific cytokine affects the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
Recombinant Human TPO produced by a mammalian expression system is a polypeptide chain containing 346 amino acids. A fully biologically active molecule; rhTPO a molecular mass of 75-90 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.