Description
Lipopolysaccharide (LPS) is a bacterial endotoxin and a major constituent of the cell walls of gram-negative bacteria. During gram-negative bacteremia or endotoxemia, LPS is the principal pathophysiological mediator by which bacteria can cause hypotension, organ failure, disseminated intravascular coagulation, or fatal shock in mammalian hosts. The removal of these endotoxins is highly necessary for downstream processes.
The ToxinEraser™ Endotoxin Removal Resin utilizes immobilized polymixin B to bind and remove pyrogens from solution. The polymixins are a family of antibiotics that contain a cationic cyclopeptide with a fatty acid chain. Polymixin B neutralizes the biological activity of endotoxins by binding to the lipid A portion of bacterial lipopolysaccharide.
Total Volume
2 ml of 50% slurry