Lipopolysaccharide (LPS) is a bacterial endotoxin, and a major constituent of the cell walls of gram-negative bacteria. During gram-negative bacteremia or endotoxemia, LPS is the principal pathophysiological mediator by which bacteria can cause hypotension, organ failure, disseminated intravascular coagulation, and fatal shock in mammalian hosts. The removal of these endotoxins is highly necessary for downstream processes but also highly difficult.
GenScript ToxinEraser is an endototoxin removal resin of high efficiency. It is based on the affinity matrix of modified polymyxin B (PMB),which allows highly efficient endotoxin removal. The final endotoxin level can be decreased to as low as 0.1 EU/ml * with repeat use of ToxinEraser™ endotoxin removal resin. * final removal efficiency may vary depending on the sample type/source.