Synonyms: 9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one
Molecular Formula: C24H15F3N4O
Molecular Weight: 432.4
Linear Structural Formula: C24H15F3N4O
Purity: >=98% (HPLC)
Storage: 2-8C
Application: Torin2 has been used:
•to examine its effect on LC3B-II levels in BORCS5- KO cells
•to determine its potent activity (IC50 less than 1 µM) against A2780-cis ovarian cancer cells
•in western blot analysis
Biochem Physiol Actions: Torin2 is a highly potent and selective ATP-competitive mTOR inhibitor. Torin2 has an IC50 of 0.25 nM and 800-fold greater selectivity for mTOR than PI3K.