Synonyms: 4-[[4-(2-Butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide; TMI 1; WAY-171318
Molecular Formula: C17H22N2O5S2
Molecular Weight: 398.5
Linear Structural Formula: C17H22N2O5S2
Purity: >=98% (HPLC)
Storage: room temp
Biochem Physiol Actions: TMI-1 (WAY-171318) is potent inhibitor of disintegrin metalloenzyme 17 (ADAM17) also known as the tumor necrosis factor-alpha (TNF-alpha) converting enzyme (TACE), and matrix metalloprotease (MMP). TMI-1 potently inhibits LPS-induced TNF-alpha secretion in human primary monocytes, and human whole blood. TMI-1 selectively induces caspase-dependent apoptosis in triple negative (TN) and ERBB2-overexpressing breast tumor cell lines.
Legal Information: Sold for research purposes under agreement from Pfizer Inc.