Synonyms: tPA
MDL No.: MFCD00166068
Storage: -20C
UNSPSC Code: 12352204
General description: Tissue Plasminogen Activator (tPA) is a protease of the S1 family (trypsin family) and is found in a wide variety of mammalian tissues, especially endothelial cells. tPA is secreted as a single chain precursor, which is cleaved to a two-chain form by plasmin. Supplied in the single chain form with a molecular weight of ~70 kDa.
Application: Tissue plasminogen activator has been used in a study to assess treatment risks of intracranial hemorrhage among patients with acute ischemic stroke. 1 Tissue plasminogen activator has also been used in a study to investigate the successful treatment of early thrombosis of HeartWare left ventricular assist devices with intraventricular thrombolytics.
Physical form: Lyophilized powder, from 100 mM PBS (pH 7.4), 3.5 mg/mL L-arginine, and 0.001% Tween(R) 80
Preparation Note: Reconstitute with dH2O to a final concentration of 1 mg/mL (e.g. 100 mug should be reconstituted in 100 muL).
RIDADR: NONH for all modes of transport
WGK Germany: 3
R Codes: 36/37/38
S Codes: 26
IOD Codes: Xi
Symbol: GHS07
Signal Word: Warning
Hazard Statements: H315-H319-H335
Precautionary statements: P261-P305 + P351 + P338