Synonym: 9-t-Butylglycylamido-minocycline hydrate, TBG-MINO, Tigecyclin, Tygacil
CAS Number: 1229002-07-6
Empirical Formula (Hill Notation): C29H39N5O8 · xH2O
Molecular Weight: 585.65 (anhydrous basis)
Other Notes
air sensitive
Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
Tigecycline is a broad spectrum glycylcycline antibiotic. Tigecycline is bacteriostatic, that inhibits protein synthesis by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. Tigecycline is active against resistant strains of gram-positive and gram-negative bacteria, avoiding the two most common mechanisms of resistance to the tetracycline antimicrobials: tetracycline efflux pump proteins and ribosomal protection proteins.
Assay: ≥98% (HPLC)
Form: powder
Optical Activity: [α]/D -160 to 170°, c = 0.15 in methanol
Color: off-white to yellow-brown
Solubility: DMSO: ≥3 mg/mL (warmed)
Storage Temp.: 2-8°C