Synonym: D-threo-2,2-Dichloro-N-(ß-hydroxy-a-[hydroxymethyl]-4-[methylsulfonyl]phenethyl)acetamide CAS Number: 5318-45-3 Empirical Formula (Hill Notation): C12H15Cl2NO5S Molecular Weigh: 356.22 Beilstein Registry Number: 2819542 EC Number: 239-355-3 MDL number: MFCD00467983 PubChem Substance ID: 24899874 Application Thiamphenicol is an antibiotic that has been used to treat chancroid in men and uncomplicated gonorrhea. It is used in studies of bacterial protein synthesis at the level of peptidyl transferase activity associated with the 23S rRNA of the 50S ribosomal subunit. It is used to study chloraniphenicol-thiamphenicol-resistance and the use of fluorinated analogs when resistance is encountered. Biochem/physiol Actions Thiamphenicol inhibits mitochondrial protein synthesis of proteins such as cytochrome c oxidase.