Synonyms: (2S)-Tetrahydro-5-oxo-2-furancarboxylic acid, [3-(trifluoromethyl)phenyl]methyl ester; (S)-2-HG-TFMB; (S)-2HG-TFMB; (S)-3-(Trifluoromethyl)benzyl 5-oxotetrahydrofuran-2-carboxylate; (S)-TFMB-2-HG; (S)-TFMB-2HG; (S)-TFMB-OTC; TFMB-(S)-2-HG; TFMB-L2HG; Trifluoromethylbenzyl-(S)-2-HG
Molecular Formula: C13H11F3O4
Molecular Weight: 288.22
Linear Structural Formula: C13H11F3O4
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: TFMB-(S)-2HG is a membrane-permeant (S)-2-hydroxyglutarate (L-2HG) precursor used in conjunction with the oncometabolite (R)-2-hydroxyglutarate (D-2HG) precursor for probing 2-HG enantiomer-specific cellular responses (typical conc used in culture: 0.5-20 mM). While both 2HG enantiomers inhibit multiple alpha-ketoglutarate (alpha-KG; 2-OG)-dependent dioxygenases by competing against alpha-KG binding, (S)-2HG is reported to be more potent against TET1/2, CeKDM7A & KDM5B (JARID1B/PLU-1). On the other hand, (R)-2HG, but not (S)-2HG, is shown to downregulate HIF-1a by promoting EglN1 (HIF prolyl hydroxylase 2; HIF-PH2; PHD2) activity.