Synonyms: (+)-Tetrandrine; (4aS,16aS)-3,4,4a,5,16a,17,18,19-Octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-16H-1,24:6,9-dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline; (S,S)-Tetrandrine; NSC 77037; Tetrandrin; (1beta)-6,6',7,12-Tetramethoxy-2,2'-dimethylberbaman
Molecular Formula: C38H42N2O6
Molecular Weight: 622.75
Linear Structural Formula: C38H42N2O6
MDL Number: MFCD08689909
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: Tetrandrine is bisbenzylisoquinoline alkaloid extracted from isolated from Stephania tetrandra S Moore that exhibits numerous pharmacological activities including anti-cancer, anti-inflammatory, negative ionotropic and chronotropic effects on myocardium, immunologic and antiallergenic effects. It has been used for treatment of tuberculosis, hyperglycemia, malaria, cancer and fever. Tetrandrine is potent calcium channel blocker. Tetrandrine targets multiple signaling pathways controlling cell cycle, apoptosis. Tetrandrine is an inhibitor of efflux pumps that reversed the clarithromycin resistance phenotype of some Mycobacterium avium complex clinical isolates.