Synonyms: 8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride; TC 2153
Molecular Formula: C7H4F3NS5 · HCl
Molecular Weight: 355.89
Linear Structural Formula: C7H4F3NS5 · HCl
Purity: >=95% (HPLC)
Storage: -20C
Biochem Physiol Actions: TC-2153 is a potent inhibitor of STEP (STriatal-Enriched protein tyrosine Phosphatase) that forms a reversible covalent bond with the catalytic cysteine in STEP. TC-2153 increases tyrosine phosphorylation of STEP substrates ERK1/2, Pyk2, and GluN2B in cell cultures. TC-2153 improves cognitive function in transgenic AD mice.