Tau-441 human, recombinant, is an isoform of Tau, variant 2N4R, having 4 microtubule binding repeats (R) and 2 amino terminal inserts (N). The uniprot identifier is P10636-8 (isoform Tau-F).It is expressed in HEK 293 cells, and is glycosylated.
Synonyms: Neurofibrillary tangle protein; PHF-tau; Paired helical filament-tau
Purity: >=95% (SDS-PAGE)
Storage: -20C
Biochem Physiol Actions: Tau-441 is a member of the Tau family of proteins. Tau is a family of neuronal microtubule-associated proteins. Six isoforms have been found that differ from each other in having either 3 or 4 binding repeats (R) of 31-32 amino acids, and from zero to 3 amino terminal inserts (N) of 29 amino acids each.Tau proteins are mainly expressed in the neurons of the central nervous system where they exert a role in stabilizing microtubules, key components of axonal transport, as well as in signal transduction. Tau proteins are subject to phosphorylation and this phenomenon regulates the association of the Tau protein with the microtubules. Deposits of Alzheimer's disease AD-associated proteins, such as hyperphosphorylated Tau, as well as other sharedmisfolded proteins, such as beta-amyloid precursor protein (beta-APP), ubiquitin, and various chaperones and protein kinases, are thought to play a pathologic role in the cognitive decline and muscular failure. Malfunctioning of Tau proteins is associated with microtubules disintegration and collapsing of the neuronal transportsystem. Among other diseases, Tau forms in cerebrospinal fluid are considered a reliable biomarker for progressive supranuclear palsy, where the levels of Tau forms ratio were significantly reduced.