Tau-441 human, recombinant, expressed in E. coli, >=90% (SDS-PAGE), lyophilized powder

MDL No.: MFCD07785735

Purity: >=90% (SDS-PAGE)

Storage: -20C

UNSPSC Code: 12352200

General description: The gene microtubule associated protein tau (MAPT) is localized on human chromosome 17q21.3. It is expressed in neurons, more specifically in axons.

Application: Human Tau-441 has been used to study the effects of tau on neuropathological changes in Alzheimer′s disease.

Biochem/physiol Actions: Microtubule associated protein tau (MAPT) plays an important role in the assembly and maintenance of the microtubule structure. Loss of expression of MAPT results in developmental delay and learning disability. The protein has been associated with pathology of Alzheimer′s disease (AD).

Biochem/physiol Actions: Isoform of Tau, variant 2N4R, having 4 microtubule binding repeats (R) and 2 amino terminal inserts (N)

Reconstitution: Lyophilized from MES, pH 6.8, containing NaCl and EGTA. When reconstituted in water to a protein concentration of 1 mg/mL, the resulting buffer will have ~50 mM MES, pH 6.8, 100 mM NaCl, and 0.5 mM EGTA.