Synonyms: 1-[2-[(3R,5S)-1-[3-(Acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-4-piperidineacetic acid; Lapaquistat acetate; TAK 475
Molecular Formula: C33H41ClN2O9
Molecular Weight: 645.14
Linear Structural Formula: C33H41ClN2O9
MDL Number: MFCD06407873
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: TAK-475 (Lapaquistat acetate) is a potent and selective squalene synthase inhibitor. TAK-475 effectively lowers low-density lipoprotein cholesterol in human. Clinical development of TAK-475 was discontinued due to hepatotoxicity seen in two patients receiving a high dose.