SUMO protease, also known as Ulp, is a protease that specifically removes small ubiquitin-related modifier (SUMO) in any recombinant SUMO fusion protein. Different from other tag removal proteases such as enterokinase (EK) and TEV which recognize a specific amino acid sequence and cut at a specific cleavage site, SUMO protease recognizes the SUMO tertiary structure and cleave it, more specifically and leaving no residual amino acids. GenScript’s SUMO Protease Animal-Free, His, is the recombinant SUMO protease fragment from Saccharomyces cerevisiae. This recombinant enzyme is expressed in E.coli and purified to obtain high yields of the active enzyme. It is produced under an animal free process, and is suitable for drug and vaccine development, manufacture and other applications. This product is designed with a C-terminal 6x His tag which can be removed after the SUMO cleavage reaction by purification using Ni2+ affinity chromatography resin (Cat. No. L00223) or Ni-charged magnetic beads (Cat. No. L00295).