Sulfuretin is an aurones flavonoid found in the extract of Rhus verniciflua. The Extract of Rhus verniciflua is known in the traditional medicine and scientific community to have anti-cancer properties.Sulfuretin, one of the major constituents of Rhus verniciflua extract was found to have anti-cancer activities via activation of caspase-3 and inhibition of PARP. Moreover, sulfuretin downregulates cyclin D proteins by increasing the expression of miR-30C, a tumor suppressor micro RNA that is studied in regulation of cell proliferation.2 Structure-activity relationships (SAR) of Sulfuretin analogs inhibits the proliferation of leukemia cancer line panel in vitro and in vivo in zebrafish and mice models.Furthermore, Sulfuretin 100mg/Kg in vivo study was beneficial in treating lymphoedema in mice.In addition, Sulfuretin has several other activities such as:
•Sulfuretin is an anti-adipogenic agent, suppressing the adipogenic factors C/EBPalpha, C/EBPbeta and PPARgamma, which are crucial regulators at the initial step of adipogenesis.
•Sulfuretin is a potent antioxidant which protects SH-SY5Y cell line from 6-OHDA induced ROS.
•Sulfuretin has antiviral activity through the inhibition of influenza virus neuraminidase in IC50 of 36muM.
Synonyms: Sulfuretin; Sulphuretin
Molecular Formula: C15H10O5
Molecular Weight: 270.24
Linear Structural Formula: C15H10O5
MDL Number: MFCD00017304
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: Anti-adipogenic, antineoplastic activity, antioxidative stress, Anti-Inflammatory