Synonyms: (2E)-2-Cyano-3-[4-hydroxy-3,5-bis(1-methylethyl)phenyl]-N-(3-phenylpropyl)-2-propenamide; (E)-N-(3-Phenylpropyl)-cyano-3,5-diisopropyl-4-hydroxycinnamamide; AG-1498; SU 1498; Tyrphostin SU 1498; Tyrphostin SU1498
Molecular Formula: C25H30N2O2
Molecular Weight: 390.52
Linear Structural Formula: C25H30N2O2
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: SU1498 is a potent and selective inhibitor of the VEGFR2 receptor kinase, Flk-1 with an IC50 value of 700 nM. SU1498 is a very weak inhibitor of PDGFR-kinase, EGFR-kinase and HER-2 kinase with IC50 values > 50 muM. SU1498 has been used to study the role of VEGFR2 (Flk-1) in a variety of biological activities including angiogenesis, tumor growth inhibition, and stem cell proliferation.