Streptokinase catalyzes hydrolysis of amide linkages. Forms a 1:1 complex with plasminogen which is then converted to streptokinase-plasmin. Both streptokinase-plasminogen and streptokinase-plasmin complexes can activate plasminogen. As a result of its interaction with human or rabbit plasminogen, streptokinase undergoes specific fragmentation.
Streptokinase is commonly used as a thrombolytic agent in the therapy of ischemic stroke. This therapy carries the important risk of intracerebral hemorrhage. Streptokinase is also used in the treatment of complicated parapneumonic effusions and empyema where adverse reactions, allergic type, are rare.
Specific Activity: ≥5,000 units/mg dry weight
Key Applications: Thrombolytic agent
Product Type: Proteins, Enzymes & Peptides
Biochemical Category: Proteins, Enzymes & Peptides
Presentation: White Lyophilized Powder
Format: Lyophilized solid
Solubility: Soluble in water
Storage & Handling: Store at -20°C, protect from light.