Staurosporine from Streptomyces sp. for molecular biology, =95% (HPLC)

Synonym: Antibiotic AM-2282

CAS Number: 62996-74-1

Empirical Formula (Hill Notation): C₂₈H₂₆N₄O₃

Molecular Weight: 466.53

Beilstein Registry Number: 1060573

MDL Number: MFCD00077402

PubChem Substance ID: 24899680

Analysis Note
Tested for inhibition of interleukin 2 production in Jurkat cells.

Biochem/physiol Actions
Potent inhibitor of phospholipid/calcium-dependent protein kinase. Inhibits the upregulation of VEGF expression in tumor cells.

Partially reverses MDR, sensitizing cells with MDR phenotype to cytotoxic agents. Inhibits Pgp phosphorylation. However, functional significance of Pgp phosphorylation is ill defined.

Application
Staurosporine from Streptomyces sp. was used to induce cell death in MDCK, 293T, Vero, HeLa, and Swiss Webster primary macrophage cells. It was used to study the effect of caspase activation on human sperm quality.