Synonyms: 2-[(4-Chlorophenyl)imino]tetrahydro-4-oxo-3-(2-tricyclo[3.3.1.13,7]dec-1-ylethyl)-2H-1,3-thiazine-6-carboxylic acid; 3-(2-Adamantanylethyl)-2-[(4-chlorophenyl)azamethylene]-4-oxo-l,3-thiazaperhyd roine-6-carboxylic acid; TT04
Molecular Formula: C23H27ClN2O3S
Molecular Weight: 446.99
Linear Structural Formula: C23H27ClN2O3S
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: ST045849 (TT04) is an O-GlcNAc transferase (OGT) Inhibitor (IC50/human splice variant = 30 muM/sOGT & 53 muM/ncOGT; 6.25 muM UDP-GlcNAc, 500 muM peptide substrate KKKYPGGSTPVSSANMM). ST045849 is typically employed in the 1-100 muM range for probing O-GlcNAcylation-dependent cellular processes in cultures, although low 10-50 nM and high 1-20 mM dosing ranges have also been reported. Daily oral administration is reported to prevent embryos neural tube defects at E10.5 among diabetic pregnant mice (20 mg/kg/day p.o. from E6.5 to E9.5).