The ssDNA/RNA Clean & Concentrator provides a simple and reliable method for the rapid separation, clean-up, and concentration of up to ~5 µg (per prep.) of single stranded DNA and/or RNA from double stranded species (e.g., genomic DNA). This simple 10 minutes procedure is based on the use of a unique single-buffer system and Zymo-Spin column technology. Single stranded DNA or RNA 17 nucleotides (e.g., transcripts, probes, primers) can be safely treated and co-purified using this kit. The result is highly concentrated, purified DNA/RNA that is suitable for subsequent molecular methods including PCR, RT-PCR, hybridization, etc.