Synonyms: ML 176; ML-176; ML176; N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)thiophene-2-sulfonamide; N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-2-thiophenesulfonamide; SR 3335; SR-3335
Molecular Formula: C13H9F6NO3S2
Molecular Weight: 405.34
Linear Structural Formula: C13H9F6NO3S2
MDL Number: MFCD02724814
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: SR3335 is a selective partial inverse agonist against the retinoic acid receptor-related orphan receptor ROR-alpha (RORalpha LBD Ki = 220 nM) that selectively inhibits the constitutive transactivation activity of RORalpha (IC50 = 480 nM), but not RORbeta, RORgamma or LXRalpha, by cell-based reporter assays without affinity toward other RORs. SR3335 effectively suppresses HepG2 cellular RORalpha target genes expression (5 muM) and improves pyruvate tolerance in DIO mice in vivo (15 mg/kg bid. Ip.) by suppressing gluconeogenesis.