Synonyms: 5-(4-Chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-carboxamide; SR-144528
Molecular Formula: C29H34ClN3O
Molecular Weight: 476.05
Linear Structural Formula: C29H34ClN3O
MDL Number: MFCD05662316
Purity: >=98% (HPLC)
Storage: -20C
Application: SR144528 has been used as a cannabinoid CB2 receptor antagonist:
•to study its blocking effect on the anti-dyskinetic functionality of HU-308
•to study its effects on spontaneous excitatory postsynaptic currents (sEPSCs) from the globus pallidus neurons
•to analyze its effect on the gastric emptying in rats
Biochem Physiol Actions: SR144528 is a potent and highly selective cannabinoid CB2 receptor inverse agonist. SR144528 exhibited a Ki of 0.6 nM at CB2 compared to 400 nM at the related CB1 receptor.