Synonyms: 4-[[3,4-Dioxo-2-[[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]amino]-1-cyclobuten-1-yl]amino]-1-piperidinecarboxylic acid ethyl ester, hydrochloride; Ethyl 4-(3,4-dioxo-2-(2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethylamino)cyclobut-1-enylamino)piperidine-1-carboxylate, hydrochloride
Molecular Formula: C25H32F3N5O4 · xHCl
Linear Structural Formula: C25H32F3N5O4 · xHCl
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: Squarunkin A is a non-cytotoxic, potent and specific UNC119-cargo interation blocker (IC50 = 10 nM against 800 nM myristoylated Src N-terminal peptide for GST-UNC119A) that targets UNC119A/B myristoyl-binding pocket without affecting the interaction of geranylgeranylated Rab1 to RhoGDI22, or farnesylated Rheb to PDE6d, AIPL1, and calmodulin. Squarunkin A blocks Lck localization at staphylococcal E enterotoxin-induced Jurkat T-cell synpase (2 muM) and prevents MDA-MB-231 cellular Src activation (37/62% reduced Src pY416 post 24 hr 78/625 nM Squarunkin A incubation) without growth inhibition or apoptosis induction (10 muM for >35 hrs).