Synonyms: 1-Isopropyl-3-(phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Molecular Formula: C16H15N5
Molecular Weight: 277.32
Linear Structural Formula: C16H15N5
MDL Number: MFCD23379049
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: SPP86 is a potent cell permeable inihbitor of RET tyrosine kinase with an IC50 value of 8 nM and with some inhibitory activity at EphA1, FGFR1, Flt4, Lck and Yes. SPP86 does not inhibit p38, CSK, KIT, PDGF, Src or BCR-ABL. SPP86 inhibited RET-mediated activation of the PI3K/Akt and MAPK pathways at doses of 0.1- 1 muM in a cell line expressing oncogenic RET and inhibited RET-induced ERalpha phosphorylation and proliferation in MCF7 cells with an IC50 value of 1.0 muM, similar to tamoxifen.