Synonyms: 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide, 4-methylbenzenesulfonate; BAY 43-9006 tosylate salt; BAY43-9006 tosylate salt; N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea, 4-methylbenzenesulfonate
Molecular Formula: C21H16ClF3N4O3·C7H8SO3
Molecular Weight: 637.03
Linear Structural Formula: C21H16ClF3N4O3·C7H8SO3
MDL Number: MFCD08235032
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: Tosylate salt of the orally active kinase inhibitor Sorafenib (BAY 43-9006) that exerts broad-spectrum anticancer efficacy in vitro and in vivo via targeting b-Raf, c-Raf (Raf-1), as well as several receptor tyrosine kinases involved in neovascularization and tumor progression, including vascular endothelial growth factor receptors 2/3 (VEGFR-2/Flk-1/KDR, VEGFR-3), platelet-derived growth factor receptor-beta (PDGFR-beta), Flt-3, c-KIT, FGFR-1 (Flt-2) and RET.